Phenotypic changes in ciprofloxacin-resistant Staphylococcus aureus.

  title={Phenotypic changes in ciprofloxacin-resistant Staphylococcus aureus.},
  author={Lili Rosana Mesak and Julian Davies},
  journal={Research in microbiology},
  volume={160 10},
The work described here continues our studies of the effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus. Mitomycin C and the new-generation fluoroquinolone moxifloxacin induced expression of SOS response genes (lexA, recA, sosA, and umuC) in a ciprofloxacin-resistant Cip(r)I strain of S. aureus. To examine phenotypic changes in Cip(r) strains mutated in CIP targets (GrlA and/or GyrA), we used Biolog Phenotype MicroArrays. Two… CONTINUE READING

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