Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

  title={Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.},
  author={Elena C S{\'a}nchez and Ajay Nadig and Bruce C. Richardson and Barry I. Freedman and Kenneth M Kaufman and Jennifer A. Kelly and Timothy B Niewold and Diane L. Kamen and Gary S. Gilkeson and Julie T. Ziegler and Carl D. Langefeld and Graciela S Alarc{\'o}n and Jeffrey C. Edberg and Rosalind Ramsey-Goldman and Michelle Petri and Elizabeth E. Brown and Robert Kimberly and John D Reveille and Luis M Vil{\'a} and Joan Tenenbaum Merrill and Juan-Manuel Anaya and Judith A James and Bernardo Antonio Pons-Estel and Javier Mart{\'i}n and So-Yeon Park and So Young Bang and S -C Bae and Kathy L. Moser and Timothy J Vyse and Lindsey A. Criswell and Patrick M Gaffney and Betty P. Tsao and Chaim O. Jacob and John Barker Harley and Marta E. Alarc{\'o}n-Riquelme and Amr H. Sawalha},
  journal={Annals of the rheumatic diseases},
  volume={70 10},
OBJECTIVE Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease. A number of genetic loci that increase lupus susceptibility have been established. This study examines if these genetic loci also contribute to the clinical heterogeneity in lupus. MATERIALS AND METHODS 4001 European-derived, 1547 Hispanic, 1590 African-American and 1191 Asian lupus patients were genotyped for 16 confirmed lupus susceptibility loci. Ancestry informative markers were genotyped to calculate… CONTINUE READING


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