Phenotypic and genotypic heterogeneity in infant acute leukemia. I. Acute lymphoblastic leukemia.

@article{Ludwig1989PhenotypicAG,
  title={Phenotypic and genotypic heterogeneity in infant acute leukemia. I. Acute lymphoblastic leukemia.},
  author={W. D. Ludwig and Claus Rainer Bartram and Jochen Harbott and Ursula Koeller and Oskar Arthur Haas and T E Hansen-Hagge and Gerhard Heil and H. Seibt-Jung and J{\"u}rgen Teichmann and Joerg Ritter},
  journal={Leukemia},
  year={1989},
  volume={3 6},
  pages={431-9}
}
We have studied the immunophenotypic and genotypic features in 35 infants aged less than 1 year with acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia (AUL). A CD10 (common ALL antigen)-negative, CD19-positive pre-pre-B ALL phenotype was observed in 24 infants. Seventeen of them had blast cells coexpressing myeloid-associated markers such as CD15A (VIM-D5, MZ17) and/or VIM-2, but neither myeloperoxidase nor platelet peroxidase was detected in five of these cases analyzed by… CONTINUE READING

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