Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.

Abstract

A panel of 10 clinical isolates of herpes simplex virus (HSV) deficient in the expression of thymidine kinase (TK) and phenotypically resistant to aciclovir was characterized. Sequence analysis revealed a variety of mutations in TK (nucleotide substitutions, insertions and deletions), most of which resulted in truncated TK polypeptides. In line with… (More)

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@article{Harris2003PhenotypicAG, title={Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to aciclovir.}, author={Wendy Harris and Peter Collins and Rob J Fenton and Wendy B Snowden and Mike Sowa and Graham Darby}, journal={The Journal of general virology}, year={2003}, volume={84 Pt 6}, pages={1393-401} }