Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment.

@article{Ishii2016PhenotypicAF,
  title={Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment.},
  author={Genichiro Ishii and Atsushi Ochiai and Shinya Neri},
  journal={Advanced drug delivery reviews},
  year={2016},
  volume={99 Pt B},
  pages={186-196}
}
Cancer microenvironment is created not only by malignant epithelial cells, but also by several kinds of stromal cells. Since Paget proposed the "seed and soil" hypothesis, the biological importance of the cancer microenvironment has come to be widely accepted. The main compartment of host stromal cells are fibroblasts (Cancer-Associated Fibroblasts; CAFs), which are the main source of the collagen-producing cells. CAFs directly communicate with the cancer cells and other types of stromal cells… CONTINUE READING
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