Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.

Abstract

BACKGROUND Trafficking of dendritic cells (DC), the primary regulators of alloimmune responses, is controlled by chemokines. Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients. METHODS AND… (More)
DOI: 10.1097/TP.0b013e31816843a0

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