• Corpus ID: 23412841

Phenotypic and functional characterization of the circulating NK compartment in hairy cell leukaemia.

  title={Phenotypic and functional characterization of the circulating NK compartment in hairy cell leukaemia.},
  author={Robin Fo{\`a} and Francesco Lauria and Paolo Lusso and Donatella Raspadori and Maria Teresa Fierro and Pier Luigi Tazzari and L Caudana and Lina Matera},
  journal={Clinical and experimental immunology},
  volume={64 2},
A phenotypic and functional analysis of the circulating natural killer (NK) cell population was carried out in a series of patients with hairy cell leukaemia (HCL). The overall mean NK activity of both the mononuclear and T cell fractions was reduced compared to that of normal controls (466 lytic units (lu) v 573 lu and 226 lu v 381 lu, respectively), though this difference did not reach statistical significance (P less than 0.05). Individual analysis of the data showed that in five out of 15… 

Natural killer cell function and malignant cell phenotype in hairy cell leukaemia

It is concluded that the level of NK function correlates closely with disease activity in HCL and that competitive target cell binding by malignant cells may be one cause of depressed NK‐cell function in hairy cell leukaemia.

Hairy cell leukaemia: observations on natural killer activity in different clinical stages of the disease

Follow‐up studies of natural killer cells, NK activity and antibody dependent cellular cytotoxicity in the course of hairy cell leukaemia were carried out in a series of patients affected by the disease, suggesting that investigation of in vitro NK cell cytot toxicity might serve as a useful adjunct in determining clinical stage in HCL.

Interleukin 2- and interferon alpha induced natural killer cell activity as a marker of progression in hairy cell leukemia.

In vitro tests showed that interferon alpha and interleukin 2 could increase the NK activity to normal levels only in HCL patients with stable disease, while in progressive HCL these cytokines showed a significantly decreased effect.

Hairy Cell Leukemia Cells are Relatively Nk‐Insensitive Targets

Hairy cells were not susceptible to lymphokine activated killer cells but were sensitive to lysis by antibody and complement, and the insensitivity to cell mediated cytolysis against hairy cells was shown by cold target inhibition to be a lack of target recognition by NK cells.

Natural-killer-stimulatory effect of combined low-dose interleukin-2 and interferon β in hairy-cell leukemia patients

It should be possible to use low-dose IL-2/IFNβ doses to treat patients suffering from other B-cell lymphoproliferative, HIV-associated disorders, all of which are characterized by a deficiency in NK activity, and to identify the lowestIL-2 and IFN β doses that would effectively boost the additive or synergic effect in a greater number of cases.

Association of large granular lymphocyte/natural killer cell proliferative disease and second hematologic malignancy

A common origin from an altered precursor cell for both myeloid and LGL proliferations in the first two cases is discussed, whereas in the third it might be related to the severe immune derangement frequently observed in hairy‐cell leukemia.

The biology of hairy cell leukemia

The work presented in this thesis has been carried out at the Division of Imrnunohematology, Department of Hematology, Aarhus University Hospital, mainly during my time as research assistant at the