Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

  title={Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.},
  author={Moira B. Glaccum and Kim L. Stocking and Keith Charrier and J. Lleweilun Smith and Cynthia Willis and Charlie Maliszewski and David J. Livingston and Jacques J. Peschon and Philip J. Morrissey},
  journal={Journal of immunology},
  volume={159 7},
IL-1 alpha and IL-1 beta bind to receptors termed the type I and type II IL-1 receptors. The type I IL-1 receptor is responsible for specific signaling, while the type II IL-1 receptor functions as a nonsignaling decoy receptor. To determine the effect of a defect in IL-1-mediated signaling, mice have been produced with a genetically disrupted type I IL-1 receptor gene. Mice lacking type I IL-1 receptors are of normal vigor and exhibit no overt phenotype. B cells from type I IL-1R-/- mice… CONTINUE READING
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