Phenotypic and functional characterization of human CD25+ B cells.

  title={Phenotypic and functional characterization of human CD25+ B cells.},
  author={Mikael Brisslert and Maria Bokarewa and P. -A. Larsson and Kajsa Wing and Laurence Vincent Collins and Andrej Tarkowski},
  volume={117 4},
We demonstrate that humans have a phenotypically and functionally distinct subset of B lymphocytes that express the interleukin (IL)-2 receptor (IL-2R) alpha-chain, cluster of differentiation (CD) 25. We found that one-third of the circulating CD20+ B cells expressed CD25 and, using fluorescence-activated cell sorter (FACS) analysis, that these cells were significantly larger and more granulated than B cells not expressing CD25. The simultaneous expression of the other two subunits (CD122 and… CONTINUE READING


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