Phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived NKT cells.

@article{Gansuvd2003PhenotypicAF,
  title={Phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived NKT cells.},
  author={Balgansuren Gansuvd and William J. Hubbard and Anne Hutchings and Francis T. Thomas and Jeanine Goodwin and Sandy Wilson and Mark Adrian Exley and Judith M. Thomas},
  journal={Journal of immunology},
  year={2003},
  volume={171 6},
  pages={2904-11}
}
Natural killer T cells are immunoregulatory cells, which have important roles in tolerance and autoimmunity, as demonstrated primarily in mice and humans. In this study, we define the phenotype and function of Valpha24(+) T cells derived from the spleens of rhesus macaques, a species increasingly used in models of immune tolerance. Valpha24(+) cells were isolated and expanded with monocyte-derived immature dendritic cells in the presence of alpha-galactosylceramide, IL-2, and IL-15. Rhesus NKT… CONTINUE READING

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