Phenotypic and functional characteristics of CD4+ CD39+ FOXP3+ and CD4+ CD39+ FOXP3neg T-cell subsets in cancer patients.

@article{Schuler2012PhenotypicAF,
  title={Phenotypic and functional characteristics of CD4+ CD39+ FOXP3+ and CD4+ CD39+ FOXP3neg T-cell subsets in cancer patients.},
  author={Patrick J. Schuler and Bastian Schilling and Malgorzata Harasymczuk and Thomas K. Hoffmann and Jonas T. Johnson and S. W. Lang and Theresa L Whiteside},
  journal={European journal of immunology},
  year={2012},
  volume={42 7},
  pages={1876-85}
}
Human CD4(+) CD39(+) regulatory T (Treg) cells hydrolyze exogenous adenosine triphosphate (ATP) and participate in immunosuppressive adenosine production. They contain two T-cell subsets whose role in mediating suppression is not understood. Frequencies of both CD4(+) CD39(+) subsets were evaluated in peripheral blood lymphocytes of 57 cancer patients and in tumor infiltrating lymphocytes (TILs) of 6 patients. CD4(+) CD39(+) and CD4(+) CD39(neg) T cells isolated using immunobeads and cell… CONTINUE READING
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