Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE.

  title={Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE.},
  author={Beate R. Berner and Magdalena Tary-Lehmann and Nicole L. Yonkers and Ali D. Askari and Paul Viktor Lehmann and Donald D. Anthony},
  journal={Cellular immunology},
  volume={235 1},
T cell dysfunction has been described in systemic lupus erythematosus (SLE). However, the specific phenotype and function of antigen-specific CD8 cells is less clear. Here we determined phenotype and function of Epstein-Barr virus (EBV)-specific CD8 cells at the single-cell level in SLE. HLA-A2-restricted EBV-BMLF-1-specific CD8 cells were enumerated by flow cytometry using tetramers in SLE and healthy control subjects. Antigen-specific CD8 cells were analyzed for expression of differentiation… CONTINUE READING


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