Phenotypic and Functional Separation of Memory and Effector Human CD 8 1 T Cells

  title={Phenotypic and Functional Separation of Memory and Effector Human CD 8 1 T Cells},
  author={D{\"o}rte Hamann and Paul A. Baars and Martin H. G. Rep and Berend Hooibrink and Susana R. Kerkhof-Garde and Michel R. Klein and Ren{\'e} A. W. van Lier},
Human CD8 1 memoryand effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8 1 T cell subset. First, CD45RA 2 CD45R0 1 cells are reminiscent of memorytype T cells in that they express elevated levels of CD95 (Fas) and the integrin family members CD11a, CD18, CD29, CD49d, and CD49e, compared to naive CD8 1 T cells, and are able to secrete not only interleukin (IL) 2 but also… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 62 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

CD282 T lymphocytes

  • M. Azuma, J. H. Phillips, L. L. Lanier
  • Antigenic and functional properties. J. Immunol
  • 1993
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…