Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

@article{Hamann1997PhenotypicAF,
  title={Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells},
  author={Dörte Hamann and Paul A. Baars and Martijn Rep and Berend Hooibrink and Susana R. Kerkhof-Garde and Michèl R. Klein and Rene A. W. van Lier},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1407 - 1418}
}
Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8+ T cell subset. First, CD45RA−CD45R0+ cells are reminiscent of memory-type T cells in that they express elevated levels of CD95 (Fas) and the integrin family members CD11a, CD18, CD29, CD49d, and CD49e, compared to naive CD8+ T cells, and are able to secrete not only interleukin (IL) 2 but also… 
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TLDR
A model of human CD8 T cell differentiation is provided in which specialized distinct subpopulations can be identified by expression of CD7, and the effector cells can functionally be divided into cytokine-secreting effectorCD8 T cells and lytic effector CD7 T cells.
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TLDR
The phenotype corresponding to the circulating effector CD8+ T cell pool may be simplified and more precisely defined by the use of just two surface markers: CD8 and CD56.
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.
TLDR
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