Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.

@article{Sfanos2008PhenotypicAO,
  title={Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.},
  author={Karen S Sfanos and Tullia C. Bruno and Charles H. Maris and Lauren F Xu and Christopher Thoburn and Angelo Demarzo and Alan K Meeker and William B Isaacs and Charles G. Drake},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 11},
  pages={3254-61}
}
PURPOSE Pathologic examination of prostate glands removed from patients with prostate cancer commonly reveals infiltrating CD4+ and CD8+ T cells. Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer. EXPERIMENTAL DESIGN We developed a technique that samples the majority of the peripheral prostate through serial needle aspirates. CD4+ prostate-infiltrating lymphocytes (PIL) were… CONTINUE READING
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