Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.

  title={Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.},
  author={Karen S Sfanos and Tullia C. Bruno and Charles H. Maris and Lauren F Xu and Christopher Thoburn and Angelo Demarzo and Alan K Meeker and William B Isaacs and Charles G. Drake},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 11},
PURPOSE Pathologic examination of prostate glands removed from patients with prostate cancer commonly reveals infiltrating CD4+ and CD8+ T cells. Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer. EXPERIMENTAL DESIGN We developed a technique that samples the majority of the peripheral prostate through serial needle aspirates. CD4+ prostate-infiltrating lymphocytes (PIL) were… CONTINUE READING
161 Citations
37 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 161 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Cutting edge : human Th 17 cells are identified as bearing CCR 2 + CCR 5 - phenotype

  • A Urisman, RJ Molinaro, N Fischer
  • J Immunol
  • 2007

Develop - ment , cytokine profile and function of human interleukin 17 - producing helperTcells

  • Chen M-L, MJ Pittet, L Gorelik
  • Nat Immunol
  • 2007

Inflamma - tion in prostate carcinogenesis

  • JL Langowski, RA Kastelein, M Oft
  • Nat Rev Cancer
  • 2007

Interleukins 1 [ h ] and 6 but not transforming growth factor - [ h ] are essential for the differentiation of interleukin 17 - producing humanT helper cells

  • NJ Wilson, K Boniface, Chan
  • Nat Immunol
  • 2007

T ( H ) - 17 cells in the circle of immunity and autoimmunity

  • GE Steiner, ME Newman, D Paikl
  • Nat Immunol
  • 2007

TGF - [ h ] and IL - 6 drive the production of IL - 17 and IL - 10 by T cells and restrain TH17 cell - mediated pathology [ advanced online publication ]

  • EV Acosta-Rodriguez, G Napolitani, A Lanzavecchia, F Sallusto
  • 2007

Similar Papers

Loading similar papers…