Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype.

@article{Wilske1995PhenotypicAO,
  title={Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype.},
  author={Bettina Wilske and Sigrid Jauris-Heipke and Ruth Lobentanzer and Ingrid Pradel and Vera Preac-Mursic and Dieter Roessler and Erwin Soutschek and R. Colin Johnson},
  journal={Journal of clinical microbiology},
  year={1995},
  volume={33 1},
  pages={103-9}
}
Molecular analyses of the genes encoding OspC, a major immunodominant protein of Borrelia burgdorferi sensu lato, revealed a considerable degree of heterogeneity. In the present study, we investigated whether a similar heterogeneity of the OspC phenotype can be shown by analysis with monoclonal antibodies (MAbs). Thirteen OspC-specific MAbs (L22 MAbs) were produced by immunizing mice with either different combinations of whole-cell antigens or recombinantly expressed OspCs cloned from strains… CONTINUE READING