Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus.

@article{Jones2007PhenotypicAO,
  title={Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus.},
  author={Louise Jones and Antony P Black and Gathsaurie Neelika Malavige and Graham S Ogg},
  journal={European journal of immunology},
  year={2007},
  volume={37 12},
  pages={3393-403}
}
Open reading frame 63 of varicella-zoster Virus (VZV) encodes an immediate early (IE) phosphoprotein (IE63) that is believed to be important for viral infectivity and establishing latency. Evidence suggests that VZV-specific T cells are crucial in the control of viral replication; however, data addressing the existence of IE63 protein-specific CD4+ T cells are limited. Using IFN-gamma immunosorbent assays, we identified high frequencies of responses to overlapping peptides spanning the IE63… CONTINUE READING