Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility.

@article{Ansari2013PhenotypicAO,
  title={Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility.},
  author={Israr-ul H. Ansari and Todd M. Allen and Andrew Berical and Peter G. Stock and Burc Barin and Rob Striker},
  journal={Virology},
  year={2013},
  volume={436 2},
  pages={268-73}
}
Hepatitis C virus (HCV) replication is limited by cyclophilin inhibitors but it remains unclear how viral genetic variations influence susceptibility to cyclosporine (cyclosporine A, CsA), a cyclophilin inhibitor. In this study HCV from liver transplant patients was sequenced before and after CsA exposure. Phenotypic analysis of NS5A sequence was performed… CONTINUE READING