Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.

@article{Metzler1999PhenotypicAO,
  title={Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.},
  author={Barbara Metzler and Christoph Burkhart and David Cameron Wraith},
  journal={International immunology},
  year={1999},
  volume={11 5},
  pages={
          667-75
        }
}
The T cell co-stimulatory receptors CD28 and CTLA-4 appear to have opposite effects on T cell activation, mediating augmentation and inhibition of T cell responses respectively. Since these two receptors use the same ligands, CD80 (B7-1) and CD86 (B7-2), the co-ordinate timing of CD28 and CTLA-4 expression has a major impact on the regulation of immune responses. While the kinetics of co-stimulatory molecules have been established for T cell stimulation in vitro, little is known about CD28 and… Expand
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