Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy

@article{Claudi2014PhenotypicVO,
  title={Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy},
  author={Beatrice Claudi and Petra Spr{\"o}te and Anna Chirkova and Nicolas Personnic and Janine Zankl and Nura Sch{\"u}rmann and Alexander J Schmidt and Dirk Bumann},
  journal={Cell},
  year={2014},
  volume={158},
  pages={722-733}
}
Antibiotic therapy often fails to eliminate a fraction of transiently refractory bacteria, causing relapses and chronic infections. Multiple mechanisms can induce such persisters with high antimicrobial tolerance in vitro, but their in vivo relevance remains unclear. Using a fluorescent growth rate reporter, we detected extensive phenotypic variation of Salmonella in host tissues. This included slow-growing subsets as well as well-nourished fast-growing subsets driving disease progression… CONTINUE READING
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Repression of the RcsC-YojN-RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence

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