Phenotypic Variation in Dentinogenesis Imperfecta/Dentin Dysplasia Linked to 4q21

  title={Phenotypic Variation in Dentinogenesis Imperfecta/Dentin Dysplasia Linked to 4q21},
  author={M. Beattie and J. Kim and S. Gong and C. Murdoch-Kinch and J. Simmer and J. Hu},
  journal={Journal of Dental Research},
  pages={329 - 333}
  • M. Beattie, J. Kim, +3 authors J. Hu
  • Published 2006
  • Biology, Medicine
  • Journal of Dental Research
  • Dentinogenesis imperfecta (DGI) and dentin dysplasia (DD) are allelic disorders that primarily affect the formation of tooth dentin. Both conditions are autosomal-dominant and can be caused by mutations in the dentin sialophosphoprotein gene (DSPP, 4q21.3). We recruited 23 members of a four-generation kindred, including ten persons with dentin defects, and tested the hypothesis that these defects are linked to DSPP. The primary dentition showed amber discoloration, pulp obliteration, and severe… CONTINUE READING
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