Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.

@article{AlAli2016PhenotypicSO,
  title={Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.},
  author={Hassan Al-Ali and Vance P. Lemmon and John L. Bixby},
  journal={Methods in molecular biology},
  year={2016},
  volume={1462},
  pages={677-88}
}
The inability of central nervous system (CNS) neurons to regenerate damaged axons and dendrites following traumatic brain injury (TBI) creates a substantial obstacle for functional recovery. Apoptotic cell death, deposition of scar tissue, and growth-repressive molecules produced by glia further complicate the problem and make it challenging for re-growing… CONTINUE READING