Phenotypic Resistance and the Dynamics of Bacterial Escape from Phage Control

  title={Phenotypic Resistance and the Dynamics of Bacterial Escape from Phage Control},
  author={J. J. Bull and Christina Skovgaard Vegge and Matthew W Schmerer and Waqas Nasir Chaudhry and Bruce R. Levin},
  booktitle={PloS one},
The canonical view of phage - bacterial interactions in dense, liquid cultures is that the phage will eliminate most of the sensitive cells; genetic resistance will then ascend to restore high bacterial densities. Yet there are various mechanisms by which bacteria may remain sensitive to phages but still attain high densities in their presence - because bacteria enter a transient state of reduced adsorption. Importantly, these mechanisms may be cryptic and inapparent prior to the addition of… CONTINUE READING
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