Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis

@inproceedings{Sirenko2016PhenotypicCO,
  title={Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis},
  author={Oksana Sirenko and Michael K. Hancock and Jayne A Hesley and Dihui Hong and Avrum Cohen and Jason Gentry and Coby B. Carlson and David A. Mann},
  booktitle={Assay and drug development technologies},
  year={2016}
}
Cell models are becoming more complex to better mimic the in vivo environment and provide greater predictivity for compound efficacy and toxicity. There is an increasing interest in exploring the use of three-dimensional (3D) spheroids for modeling developmental and tissue biology with the goal of accelerating translational research in these areas… CONTINUE READING