Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.

  title={Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels.},
  author={Connor A Emdin and Amit V. Khera and Pradeep Natarajan and Derek Klarin and Hong-Hee Won and Gina Marie Peloso and Nathan O. Stitziel and Akihiro Nomura and Seyedeh Maryam Zekavat and Alexander G Bick and Namrata Gupta and Rosanna Asselta and Stefano Duga and Piera Angelica Merlini and Adolfo Correa and Thorsten Kessler and James G. Wilson and Matthew J. Bown and Alistair Scott Hall and Peter S. Braund and Nilesh J. Samani and Heribert Schunkert and Jaume Marrugat and Roberto Elos{\'u}a and Ruth Mcpherson and Martin Farrall and Hugh C Watkins and Cristen J. Willer and Gonçalo R. Abecasis and Janine F. Felix and Ramachandran S. Vasan and Eric S. Lander and Daniel J. Rader and John Danesh and Diego Ardissino and Stacey Bolk Gabriel and Danish Saleheen and Sekar Kathiresan},
  journal={Journal of the American College of Cardiology},
  volume={68 25},
BACKGROUND Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has emerged as a therapeutic strategy. Beyond target identification, human genetics may contribute to the development of new therapies by defining the full spectrum of beneficial and adverse consequences and by developing a dose-response curve of target perturbation. OBJECTIVES… CONTINUE READING


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