Phenotypic Alterations Involved in CD8+ Treg Impairment in Systemic Sclerosis

Abstract

Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis, vasculopathy, and autoimmunity. Although the exact pathogenetic mechanisms behind SSc remain to be fully elucidated, a great deal of evidence suggests the existence of an unbalanced ratio between the effector and regulatory arms of the immune system. With regard to the… (More)
DOI: 10.3389/fimmu.2017.00018

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