Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

@article{Chiga2011PhenotypesOP,
  title={Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.},
  author={Motoko Chiga and Fatema H. Rafiqi and Dario R Alessi and Eisei Sohara and Akihito Ohta and Tatemitsu Rai and Sei Sasaki and Shinichi Uchida},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 9},
  pages={
          1391-5
        }
}
We recently reported increased phosphorylation of the NaCl cotransporter (NCC) in Wnk4(D561A/+) knock-in mice, an ideal model of the human hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII). Although previous in vitro studies had suggested the existence of a phosphorylation cascade involving the WNK, OSR1 and SPAK kinases, whether the WNK-OSR1/SPAK cascade is in fact fully responsible for NCC phosphorylation in vivo and whether the activation of this cascade is the sole… CONTINUE READING

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