Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.

@article{Strong2011PhenotypesIM,
  title={Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.},
  author={Margaret A. Strong and Sofia L. Vidal-Cardenas and Baktiar O. Karim and Huimin Yu and Nini Guo and Carol W Greider},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 12},
  pages={2369-79}
}
Telomerase is essential for telomere length maintenance. Mutations in either of the two core components of telomerase, telomerase RNA (TR) or the catalytic protein component telomerase reverse transcriptase (TERT), cause the genetic disorders dyskeratosis congenita, pulmonary fibrosis, and other degenerative diseases. Overexpression of the TERT protein has been reported to have telomere length-independent roles, including regulation of the Wnt signaling pathway. To examine the phenotypes of… CONTINUE READING
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