Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.

@article{Shiloh1999PhenotypeOM,
  title={Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.},
  author={Michael U Shiloh and John D Macmicking and S Nicholson and J E Brause and Sarah Potter and Maria Marino and Flora Fang and Mary Dinauer and Carl Nathan},
  journal={Immunity},
  year={1999},
  volume={10 1},
  pages={29-38}
}
The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics. Neither parental strain showed such infections… CONTINUE READING
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