Phenotype of chromosome 14-linked familial Alzheimer's disease in a large kindred.

@article{Lampe1994PhenotypeOC,
  title={Phenotype of chromosome 14-linked familial Alzheimer's disease in a large kindred.},
  author={Thomas H. Lampe and Thomas Bird and David Nochlin and Ellen Nemens and Steven C. Risse and Shinichi Sumi and R M Koerker and B Leaird and Megan Wier and Murray A. Raskind},
  journal={Annals of neurology},
  year={1994},
  volume={36 3},
  pages={
          368-78
        }
}
We report the clinical and neuropathological features of chromosome 14-linked familial Alzheimer's disease (14qFAD) in affected members of the L family. Some clinical information on all 16 known affected individuals and detailed neuropathological findings in 6 family members were available for review. Common features of the phenotype of 14qFAD in the L family included onset of dementia before the age of 50, early progressive aphasia, early-appearing myoclonus and generalized seizures, paratonia… CONTINUE READING
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