Phenotype and steroidogenic potential of PDGFRα-positive rat neonatal peritubular cells.

@article{Landreh2013PhenotypeAS,
  title={Phenotype and steroidogenic potential of PDGFRα-positive rat neonatal peritubular cells.},
  author={Luise Landreh and Jan-Bernd Stukenborg and Olle S{\"o}der and Konstantin V Svechnikov},
  journal={Molecular and cellular endocrinology},
  year={2013},
  volume={372 1-2},
  pages={96-104}
}
Platelet-derived growth factor receptor α (PDGFRα)-positive peritubular cells (PTCs) are suggested to be putative stem Leydig cells. At present little is known about their phenotype and steroidogenic potential. We isolated highly purified PDGFRα-positive neonatal PTCs by magnetic cell sorting (MACS) from 8dpp rat testes and characterized them in vitro. We have demonstrated that PDGFRα-positive PTCs have a mixed phenotype. They expressed PTC-specific genes (αSma, Myh11), pluripotency markers… CONTINUE READING