Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.

@article{Duraiswamy2011PhenotypeFA,
  title={Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.},
  author={Jaikumar Duraiswamy and Chris C. Ibegbu and David Masopust and Joseph D. Miller and Koichi Araki and Gregory Doho and Pramila Tata and Satish Gupta and Michael J. Zilliox and Helder I. Nakaya and Bali Pulendran and W Nicholas Haining and Gordon J Freeman and Rafi Ahmed},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={4200-12}
}
T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that programmed death-1 (PD-1) regulates T cell dysfunction during chronic lymphocytic choriomeningitis virus infection in mice, and PD-1(hi) cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, hepatitis C virus, and hepatitis B virus. However, it is not known if PD-1(hi) cells of healthy humans have the traits of exhausted… CONTINUE READING

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