Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.

@article{ChamounEmanuelli2013PhenothiazinesIH,
  title={Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.},
  author={Ana M. Chamoun-Emanuelli and Eve-Isabelle P{\'e}cheur and Rudo L. Simeon and Da Huang and Paul S Cremer and Zhilei Chen},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 6},
  pages={2571-81}
}
Despite recent progress in the development of direct-acting antiviral agents against hepatitis C virus (HCV), more effective therapies are still urgently needed. We and others previously identified three phenothiazine compounds as potent HCV entry inhibitors. In this study, we show that phenothiazines inhibit HCV entry at the step of virus-host cell fusion, by intercalating into cholesterol-rich domains of the target membrane and increasing membrane fluidity. Perturbation of the alignment… CONTINUE READING
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