Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.

@article{Kristiansen2003PhenothiazinesAR,
  title={Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.},
  author={Malthe M Kristiansen and Clara Leandro and Diane J. Ordway and Marta Martins and Miguel Viveiros and Teresa Pacheco and Jette Elisabeth Kristiansen and Leonard Amaral},
  journal={International journal of antimicrobial agents},
  year={2003},
  volume={22 3},
  pages={
          250-3
        }
}
Mechanisms of antibiotic resistance of bacteria include efflux pumps which extrude the antibiotic prior to reaching its target. Phenothiazines inhibit the activity of some efflux pumps thereby altering the susceptibility of bacteria. This study demonstrated that chlorpromazine and thioridazine reduce the susceptibility of methicillin-resistant strains (MRSA) but not that of methicillin-susceptible Staphylococcus aureus (MSSA) strains to oxacillin (MIC of oxacillin reduced from >500 to 10 mg/l… CONTINUE READING

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