Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart.


Recent studies have identified several chloride (Cl-) channel genes in the heart, including CFTR, ClC-2, ClC-3, CLCA, Bestrophin, and TMEM16A. Gene targeting and transgenic techniques have been used to delineate the functional role of cardiac Cl- channels in the context of health and disease. It has been shown that Cl- channels may contribute to cardiac… (More)
DOI: 10.1113/jphysiol.2008.165860


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