Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols

@article{Abdallah2016PhenolicsFG,
  title={Phenolics from Garcinia mangostana Inhibit Advanced Glycation Endproducts Formation: Effect on Amadori Products, Cross-Linked Structures and Protein Thiols},
  author={Hossam Mohamed Abdallah and Hany M El-Bassossy and Gamal A. Mohamed and Ali M. El-Halawany and Khalid Z. Alshali and Zainy Mohammed Banjar},
  journal={Molecules},
  year={2016},
  volume={21}
}
Accumulation of Advanced Glycation Endproducts (AGEs) in body tissues plays a major role in the development of diabetic complications. Here, the inhibitory effect of bioactive metabolites isolated from fruit hulls of Garcinia mangostana on AGE formation was investigated through bio-guided approach using aminoguanidine (AG) as a positive control. Including G. mangostana total methanol extract (GMT) in the reaction mixture of bovine serum albumin (BSA) and glucose or ribose inhibited the… 
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TLDR
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