Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents.

@article{Qiu2020PhenolicamineCM,
  title={Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents.},
  author={Hua Qiu and Qiufen Tu and Pengyu Gao and Xiangyang Li and Manfred F. Maitz and Kaiqin Xiong and Nan Huang and Zhilu Yang},
  journal={Biomaterials},
  year={2020},
  volume={269},
  pages={
          120626
        }
}
Antithrombogenicity, anti-inflammation, and rapid re-endothelialization are central requirements for the long-term success of cardiovascular stents. In this work, a plant-inspired phenolic-amine chemistry strategy was developed to combine the biological functions of a plant polyphenol, tannic acid (TA), and the thrombin inhibitor bivalirudin (BVLD) for tailoring the desired multiple surface functionalities of cardiovascular stents. To realize the synergistic modification of TA and BVLD on a… Expand
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