Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents.

  title={Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents.},
  author={Hua Qiu and Qiufen Tu and Pengyu Gao and Xiangyang Li and Manfred F. Maitz and Kaiqin Xiong and Nan Huang and Zhilu Yang},
Antithrombogenicity, anti-inflammation, and rapid re-endothelialization are central requirements for the long-term success of cardiovascular stents. In this work, a plant-inspired phenolic-amine chemistry strategy was developed to combine the biological functions of a plant polyphenol, tannic acid (TA), and the thrombin inhibitor bivalirudin (BVLD) for tailoring the desired multiple surface functionalities of cardiovascular stents. To realize the synergistic modification of TA and BVLD on a… Expand
5 Citations
Application of a Reactive Oxygen Species-Responsive Drug-Eluting Coating for Surface Modification of Vascular Stents.
This drug-loaded oxidative stress-responsive coating has been demonstrated to significantly inhibit inflammation, accelerate endothelialization, and reduce the risk of restenosis of vascular stents in vivo. Expand
Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel
An ultrathin anti-thrombogenic covalently attached monolayer based on monoethylene glycol silane chemistry functions by forming an interstitial hydration layer which displays restricted mobility in the prevention of surface fouling. Expand
Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model.
The results showed that the BVLD/REDV co-modified ePTFE vascular grafts had a satisfactory patency rate and a higher endothelial cell coverage ratio at 12 weeks after implantation, thereby yielding a potent product to meet the clinical needs. Expand
In-Situ-Sprayed Dual-Functional Immunotherapeutic Gel for Colorectal Cancer Postsurgical Treatment.
  • X. Si, Guofeng Ji, +7 authors Xuesi Chen
  • Medicine
  • Advanced healthcare materials
  • 2021
In a subcutaneous murine CRC model, the in-situ-sprayed immunotherapeutic gel loaded with anti-OX40 antibody results in complete inhibition on tumor recurrence and cured mice show resistance to tumor re-challenge, suggesting that immune memory effects are established after the iSGels@aOX40 treatment. Expand
A biomimetic orthogonal-bilayer tubular scaffold for the co-culture of endothelial cells and smooth muscle cells
  • Mei-Xi Li, Lei Li, +6 authors Da-Yong Wu
  • Chemistry
  • RSC Advances
  • 2021
To mimic blood vessels, a polycaprolactone tubular scaffold was prepared via electrospinning and winding. Endothelial cells were cultured on the inner layer with axial nanofibers and smooth muscleExpand


Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO2 nanotubes for improved vascular biocompatibility.
The design strategy for the BVLD-eluting nanotubular TiO2 system creates a favorable microenvironment for durable thromboresistance and the promotion of re-endothelialization, and thus it is suitable for the long-term treatment of cardiovascular diseases. Expand
Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices.
In vivo results indicate that the BVLD-PPAam surface restrained thrombus formation by rapidly growing a homogeneous and intact endothelium on its surface, suggesting the potential of this multifunctional BV LD-P PAam coating for the application not only in general vascular devices such as catheters, tubes, oxygenator, hemodialysis membranes but also vascular grafts and stents. Expand
Linker-free covalent immobilization of heparin, SDF-1α, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation.
The surface-functionalized PTFE exhibits reduced thrombogenicity, facilitates the recruitment of endothelial progenitor cells, and even alleviates the inflammatory immune responses of monocytes-macrophages and is thus promising to the development of small-diameter prosthetic vascular grafts with good long-term patency. Expand
Gallic acid tailoring surface functionalities of plasma-polymerized allylamine-coated 316L SS to selectively direct vascular endothelial and smooth muscle cell fate for enhanced endothelialization.
Gallic acid (GA) was explored to tailor such a multifunctional stent surface combined with plasma polymerization technique and showed remarkable enhancement in the adhesion, viability, proliferation, migration, and release of nitric oxide of human umbilical vein endothelial cells (HUVECs). Expand
From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading
It is demonstrated that such a “from surface to bulk synergetic modification” film engineering can impart the modified-substrates with anti-platelet and anti-coagulant dual functions, giving rise to a highly endothelium-mimetic thromboresistant property. Expand
Mussel-inspired catalytic selenocystamine-dopamine coatings for long-term generation of therapeutic gas on cardiovascular stents.
A "one-pot" method inspired by mussel adhesive proteins for copolymerization of selenocystamine and dopamine to form a NO-generating coating on a 316 L stainless steel (SS) stent found that the developed SeCA/Dopa coatings could release NO in a controllable and stable manner for more than 60 days. Expand
Enhanced biocompatibility of CD47-functionalized vascular stents.
It is concluded that CD47-modified stent surfaces mitigate platelet and inflammatory cell attachment, thereby disrupting ISR pathophysiology. Expand
Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules.
The surface coimmobilized with the anti-CD34 antibody and VEGF presented significant enhancement in the capture of endothelial progenitor cells (EPCs) and the growth of human umbilical vein endothelial cells (HUVECs), suggesting the huge potential of such polyfunctional coating for tailoring the desired interfacial properties of materials through selectively conjugating two or more diverse bioactive molecules with synergic action. Expand
Immobilization of DNA aptamers via plasma polymerized allylamine film to construct an endothelial progenitor cell-capture surface.
A facile two-step method aimed at constructing a coating with specific EPC capturing aptamers is reported, demonstrating that the EPC aptamer has large potential for designing an EPC captured stent and other vascular grafts with targeted in situ endothelialization. Expand
Plant-inspired gallolamine catalytic surface chemistry for engineering an efficient nitric oxide generating coating.
The resulting NO-generating coating with phenolic-cystamine or -selenocystamine framework showed the ability for long-term, steady and controllable range of NO release rates being unparalleled with any existing NO-releasing or NO- Generating surface engineering toolkits. Expand