Phenol-induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion.

@article{Murray2007PhenolinducedIV,
  title={Phenol-induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion.},
  author={A. Murray and E. Kisin and V. Castranova and C. Kommineni and M. Gunther and A. Shvedova},
  journal={Chemical research in toxicology},
  year={2007},
  volume={20 12},
  pages={
          1769-77
        }
}
A variety of phenolic compounds are utilized in industry (e.g., for the production of phenol (PhOH)-formaldehyde resins, paints and lacquers, cosmetics, and pharmaceuticals). They can be toxic to skin, causing rash, dermal inflammation, contact dermatitis, depigmentation, and cancer promotion. The biochemical mechanisms for the dermal toxicity of phenolic compounds are not well understood. We hypothesized that topical PhOH exposure results in the generation of radicals, possibly via redox… Expand
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