Phenol Toxicity Following Cutaneous Exposure to Creolin®: A Case Report

  title={Phenol Toxicity Following Cutaneous Exposure to Creolin{\textregistered}: A Case Report},
  author={David Vearrier and Dorian Jacobs and Michael I. Greenberg},
  journal={Journal of Medical Toxicology},
IntroductionPhenol is a caustic that may cause cutaneous or gastrointestinal burns depending on the route of exposure. [...] Key MethodCase reportA 9-year-old girl was exposed to Creolin®, a general-purpose disinfectant containing phenol, when her mother applied this product to her head and upper torso. The patient required endotracheal intubation due to depressed mental status; she had cutaneous erythema in the distribution of contact with the cleanser.Expand
Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
It is suggested that Creolin® exhibited an antiophidian effect only when it is mixed with the venom and administered intramuscularly.
Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds)
Medicinal thermal waters consist of a mixture of different organic and inorganic compounds. Traditionally, these waters are only characterized and classified by their inorganic composition; however,
Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.
The discovery and optimization of Δ-5 desaturase (D5D) inhibitors are described, with the discovery of (4S,5S)-5i, a derivative with improved metabolic stability and robust in vivo hepatic arachidonic acid/dihomo-γ-linolenic acid ratio reduction in an atherosclerosis mouse model.
Caracterización clínica de los pacientes ingresados por miasis en el Hospital del Niño Dr. Francisco de Icaza Bustamante, Guayaquil, Ecuador
Es necesario realizar actividades encaminadas a the prevencion of the enfermedad en la comunidad y the elaboracion of adecuados protocolos de manejo in las unidades de salud.


A five year evaluation of acute exposures to phenol disinfectant (26%).
The absence of serious toxicity and major chemical burns in this series does not eliminate concern with the corrosive and systemic risks of phenol poisoning.
Phenol intoxication in a child.
The case of an 11-year-old boy with a diagnosis of xeroderma pigmentosum who underwent mechanical dermabrasion and chemical peeling with phenol and then developed severe cardiac arrhythmias is reported, and a serious systemic toxic effect on cardiac rhythm from cutaneously applied phenol occurred in this case.
Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin
It was concluded that PEG 400 and 70% IPA were superior to the other treatments investigated and equally efficacious in the reduction of phenol-induced skin damage.
An autopsy case of poisoning by massive absorption of cresol a short time before death.
It was concluded that about 340 microg/ml of the total cresols was absorbed in a very short period following oral ingestion of saponated cresol solution in this case.
Decontamination procedures for skin exposed to phenolic substances.
The PEG-300/IMS mixture has been shown not to cause eye irritation, and so should not present a hazard where this mixture is used as a decontaminant spray.
Phenol poisoning.
The patient developed coma, respiratory arrest 30 minutes postingestion, hypotension, ventricular arrhythmias, metabolic acidosis, seizures, selective elevation of uric acid and gastrointestinal disturbances.
Effects of isopropyl alcohol, ethanol, and polyethylene glycol/industrial methylated spirits in the treatment of acute phenol burns.
Isopropyl alcohol and polyethylene glycol with industrial methylated spirits are equally effective in the amelioration of phenol burns of less than 5% total surface area, which makes it potentially the most useful treatment for these small burns.
Cardiac arrhythmias in phenol face peeling: A suggested protocol for prevention
Further recommendations for the prevention of cardiac arrhythmias are presented, including maintaining the patient with a sufficient fluid load, forcing diuresis with furosemide, and using lidocaine hydrochloride as a prophylactic antiarrhythmic agent.
Metabolism of [14C]phenol in the isolated perfused mouse liver.
The results suggest that enzymes involved in P hydroxylation are generally closer to the central vein than those involved in conjugation, and that during retrograde perfusion, P metabolism may be limited by the sub-optimal conditions of perfusion.
Cardiac arrhythmias during phenol face peeling.
The duration of the cardiac arrhythmias suggests that the risk of cardiac arrHythmia in phenol peeling can be reduced by dividing the face into several units and spacing the application of phenol to each unit 20 minutes apart.