Phenobarbital induction of procyclidine Metabolism: in vitro study

Abstract

After pretreatment of adult male Wistar rats with phenobarbital, a well-known cytochrome P-450 inductor, the liver microsomal cytochrome P-4S0 content increased significantly compared to that of control rats. At the same time the amount of procyclidine, metabolized by the 9000 g supernatant fraction of rat liver homogenate fortified with a NADPH generating… (More)
DOI: 10.1007/BF03189569

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