Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism.

@article{Larsen1995PhenobarbitalIO,
  title={Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: genetic differences in a common regulatory mechanism.},
  author={Michele Campaigne Larsen and Colin R Jefcoate},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={321 2},
  pages={467-76}
}
The phenobarbital induction of five responsive hepatic cytochrome P450 genes is highly strain selective, particularly in female rats (Fischer >> Wistar Furth). We have shown that this strain variation represents a systematic difference in the endocrine-mediated suppression of phenobarbital induction which points to a common signaling process for each of these genes. Immunoblot analysis revealed that the strain-specific differences of phenobarbital responsiveness (10-fold for CYP2B1, CYP2B2, and… CONTINUE READING

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