Phenobarbital-induced expression of cytochrome P450 genes.

  title={Phenobarbital-induced expression of cytochrome P450 genes.},
  author={Piotr Czekaj},
  journal={Acta biochimica Polonica},
  volume={47 4},
In contrast to the well-known Ah receptor-mediated regulation of the CYP1A1 gene by polycyclic aromatic hydrocarbons, the molecular mechanism by which phenobarbital (PB) and PB-like inducers affect transcription of CYP genes remains unknown; no receptor for these chemicals has been found to date. However, in the last 5 years PB-responsive sequences have… CONTINUE READING