Phenobarbital-induced alterations in vitamin D metabolism.

  title={Phenobarbital-induced alterations in vitamin D metabolism.},
  author={Theodore J. Hahn and Stanley J. Birge and C R Scharp and Louis V. Avioli},
  journal={The Journal of clinical investigation},
  volume={51 4},
The metabolic fate of intravenously injected vitamin D(3)-1,2-(3)H (D(3)-(3)H) was studied in two normal individuals on chronic phenobarbital therapy. Silicic acid column chromatography of lipid-soluble plasma extracts obtained serially for 96 hr after D(3)-(3)H injection demonstrated a decreased plasma D(3)-(3)H half-life and increased conversion to more polar metabolites. The polar metabolites formed included several with chromatographic mobility similar to known biologically inactive vitamin… CONTINUE READING


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