Phenobarbital in the prophylaxis of late posttraumatic seizures

@article{Murri1992PhenobarbitalIT,
  title={Phenobarbital in the prophylaxis of late posttraumatic seizures},
  author={Prof. L. Murri and A. -P. Arrigo and Ubaldo Bonuccelli and Giuseppe De Rossi and Giuliano Francesco Parenti},
  journal={The Italian Journal of Neurological Sciences},
  year={1992},
  volume={13},
  pages={755-760}
}
390 patients with severe head injuries were treated with phenobarbital (PB) orally for a period of 12 months in order to determine whether this drug could reduce the incidence of posttraumatic epilepsy (PTE). An intramuscular PB dose of 2.5–3 mg/kg body weight per day was administered within 24 hours after the trauma; after 5 days, or longer if the coma persisted, the drug was administered orally. Maintenance dosage adjustments, when necessary, were based on serial plasma concentrations of the… CONTINUE READING
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