Phenobarbital for febrile seizures--effects on intelligence and on seizure recurrence.

  title={Phenobarbital for febrile seizures--effects on intelligence and on seizure recurrence.},
  author={Jacqueline R. Farwell and Yoon Jin Lee and Deborah G Hirtz and Stephen Sulzbacher and Jonas H. Ellenberg and Karin B Nelson},
  journal={The New England journal of medicine},
  volume={322 6},
Phenobarbital is widely used in the treatment of children with febrile seizures, although there is concern about possible behavioral and cognitive side effects. In 217 children between 8 and 36 months of age who had had at least one febrile seizure and were at heightened risk of further seizures, we compared the intelligence quotients (IQs) of a group randomly assigned to daily doses of phenobarbital (4 to 5 mg per kilogram of body weight per day) with the IQs of a group randomly assigned to… CONTINUE READING
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