Phenobarbital blockade of the preovulatory LH surge : Association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period 1 gene expression

@inproceedings{Legan2009PhenobarbitalBO,
  title={Phenobarbital blockade of the preovulatory LH surge : Association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period 1 gene expression},
  author={Sandra J. Legan and Kathleen M. Donoghue and Kathleen M. Franklin and Marilyn J. Duncan},
  year={2009}
}
The suprachiasmatic nucleus (SCN) controls the timing of the preovulatory LH surge in laboratory rodents. Barbiturate administration during a critical period on proestrus delays the surge and prolongs the estrous cycle one day. Because a non-photic timing signal (zeitgeber) during the critical period that phase advances activity rhythms can also induce the latter effect, we hypothesized that barbiturates delay the LH surge by phase-advancing its circadian timing signal beyond the critical… CONTINUE READING
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