Phenobarbital Confers its Diverse Effects by Activating the Orphan Nuclear Receptor Car

@article{Kodama2006PhenobarbitalCI,
  title={Phenobarbital Confers its Diverse Effects by Activating the Orphan Nuclear Receptor Car},
  author={S. Kodama and M. Negishi},
  journal={Drug Metabolism Reviews},
  year={2006},
  volume={38},
  pages={75 - 87}
}
In the early 1960s, phenobarbital (PB) was shown to induce hepatic drug metabolism and the induction was implicated in the molecular mechanism of drug tolerance development. Since then, it has become evident that PB not only induces drug metabolism, but also triggers pleiotropic effects on liver function, such as cell growth and communication, proliferation of the endoplasmic reticulum, tumor promotion, glucose metabolism, steroid/thyroid hormone metabolism, and bile acid synthesis. Upon… Expand
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References

SHOWING 1-10 OF 67 REFERENCES
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital.
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
CAR, driving into the future.
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene
...
1
2
3
4
5
...