Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity

  title={Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity},
  author={Zhengyi Li and Dong Young Choi and Eun-joo Shin and Randy Lee Hunter and Chun Hui Jin and M Wie and Min Soo Kim and Seok Joo Park and Guoying Bing and Hyoung-Chun Kim},
  journal={Neuroscience Letters},
Anti-inflammatory drugs such as ibuprofen appear to prevent the development of Parkinson's disease (PD); however, long-term use has undesirable side-effects. A new strategy for anti-inflammatory drug therapy is using a dual inhibitor of COX and lipooxygenase (LOX). Here, we compared the dopaminergic neuroprotective property of phenidone (a dual COX and LOX inhibitor) with COX or LOX inhibitors including SC-560 (a COX-1 inhibitor), aspirin (a COX-1/2 inhibitor), meloxicam (a preferential COX-2… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations


Publications referenced by this paper.
Showing 1-10 of 34 references

Neuroprotectionwith pioglitazone against LPS insult on dopaminergic neurons may be associated with its inhibition of NF - kappaB and JNK activation and suppression of COX - 2 activity

M. Liu Xing, G. Bing
J . Neuroimmunol . • 2007

Possible involvement of 12 - lipoxygenase activation in glucose - deprivation / reload - treated neurons

C. N. Oliver, B. W. Ahn, E. J. Moerman, S. Goldstein
Neurosci . Lett . • 2007