Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity

@article{Li2008PhenidonePT,
  title={Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity},
  author={Zhengyi Li and Dong Young Choi and Eun-joo Shin and Randy Lee Hunter and Chun Hui Jin and M Wie and Min Soo Kim and Seok Joo Park and Guoying Bing and Hyoung-Chun Kim},
  journal={Neuroscience Letters},
  year={2008},
  volume={445},
  pages={1-6}
}
Anti-inflammatory drugs such as ibuprofen appear to prevent the development of Parkinson's disease (PD); however, long-term use has undesirable side-effects. A new strategy for anti-inflammatory drug therapy is using a dual inhibitor of COX and lipooxygenase (LOX). Here, we compared the dopaminergic neuroprotective property of phenidone (a dual COX and LOX inhibitor) with COX or LOX inhibitors including SC-560 (a COX-1 inhibitor), aspirin (a COX-1/2 inhibitor), meloxicam (a preferential COX-2… CONTINUE READING

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