Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

@article{Wang2011PhenethylIS,
  title={Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.},
  author={Xiantao Wang and Sudha Govind and Shyama Prasad Sajankila and Lixin Mi and Rabindra K. Roy and Fung-Lung Chung},
  journal={Molecular nutrition & food research},
  year={2011},
  volume={55 10},
  pages={1572-81}
}
SCOPE Naturally-occurring chemopreventive agent phenethyl isothiocyanate (PEITC), derived primarily from watercress, has been shown to inhibit cell growth and induce apoptosis in cancer cells. In this study, we examined the potential of PEITC in enhancing cisplatin-induced apoptosis in cervical cancer cells and its mechanisms. METHODS AND RESULTS HeLa cells were exposed to PEITC, cisplatin or both. Pretreatment of cells with PEITC strongly enhanced cisplatin-induced cytotoxicity. PEITC… CONTINUE READING

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