Phenethyl caffeate benzoxanthene lignan is a derivative of caffeic acid phenethyl ester that induces bystander autophagy in WiDr cells

@article{Vijayakurup2013PhenethylCB,
  title={Phenethyl caffeate benzoxanthene lignan is a derivative of caffeic acid phenethyl ester that induces bystander autophagy in WiDr cells},
  author={Vinod Vijayakurup and Carmela Spatafora and Corrado Tringali and Padmakrishnan Chorakkode Jayakrishnan and Priya Srinivas and Srinivas Gopala},
  journal={Molecular Biology Reports},
  year={2013},
  volume={41},
  pages={85-94}
}
We recently reported that Phenethyl caffeate benzoxanthene lignan (PCBL), a semisynthetic compound derived from Caffeic Acid Phenethyl Ester (CAPE), induces DNA damage and apoptosis in tumor cells. In this study, we further investigated whether PCBL induces autophagy in WiDr cells. We also analyzed the pathways regulating autophagy and the role of autophagy in PCBL-induced cell death. Our acridine orange staining and LC3 II expression results suggest that PCBL induces autophagosomes in WiDr… CONTINUE READING